In short, legalize all drugs and criminalize federal enforcement.

In long:

• Create laws similar to alcohol about the distribution of drugs.
• Create laws about safe handling of drugs
• License distributors and tax sales to support DUI policing and potentially addiction services and a public drug information site

Where to Start?

Drug legalization.

• Find politicians in your voting district that support legalization and support them
• Convince existing politicians to support legalization (usually by being very annoying)
• Elect Sheriffs that will not cooperate with Feds on the matter of drugs
• Convince more people of the problems of the Drug War and the need to stop it